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The Effect of Aging and Interval between Primary and Secondary Treatment in Two-Stage Carcinogenesis on Mouse Skin¹

Laboratory of Organic Chemistry and Carcinogenesis, Institute of Environmental Medicine [B. L. V. D., A. S., C. K., S. M.], and Department of Pathology [I. S.], New York University Medical Center, New York, New York, 10016

Two-stage carcinogenesis experiments on mouse skin (female ICR/Ha Swiss mice) were done by initiating mice at three age levels (6, 44, and 56 weeks) and promoting after a 2-week interval. In another series, mice were initiated at age 6 weeks, and three time intervals (2, 36, and 56 weeks) were used between initiation and promotion. The initiating agent was 7,12-dimethylbenz(a)anthracene and the promoting agent was phorbol myristate acetate in all experiments. The results showed a general decrease in tumor production with increasing age at the time of promotion. However, the initiating effect persisted even when the interval between initiation and promotion was 56 weeks.

¹ This work was supported by USPHS Grants CA-15095 from the National Cancer Institute and ES-00260 from the National Institutes of Environmental Health Sciences.

Received 8/ 5/74. Accepted 11/20/74.

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