This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Shirasaka, T. Articles by Fujii, S. Search for Related Content PubMed PubMed Citation Articles by Shirasaka, T. Articles by Fujii, S.

DNA Synthesis in Tumor-bearing Rats¹

Department of Enzyme Physiology, Institute for Enzyme Research, School of Medicine, Tokushima University, Tokushima, Japan

Thymidine (TdR) incorporation into DNA increased in the livers and spleens of rats bearing Yoshida sarcoma (solid type) or AH130 (solid type). TdR kinase and DNA polymerase activities increased in the serum, liver, and spleen of these rats; while thymidine monophosphate kinase activity increased appreciably only in the liver and spleen. On diethylaminoethyl cellulose column chromatography, 2 peaks of TdR kinase activity were separated from the serum and tumor tissues of rats bearing Yoshida sarcoma (solid type) while only 1 peak was obtained from the liver. TdR kinase activity in the serum decreased abruptly 7 hr after removal of the Yoshida sarcoma, while that in the liver decreased more slowly.

¹ Supported in part by a grant for Cancer Research from the Ministry of Welfare of Japan.

Received 5/21/74. Accepted 10/11/74.