This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Baker, D. G. Articles by Yaffe, A. H. Search for Related Content PubMed PubMed Citation Articles by Baker, D. G. Articles by Yaffe, A. H.

The Influence of Thyroid Stimulation on the Incidence of 3-Methylcholanthrene-induced Tumors¹

Claire Zellerbach Saroni Tumor Institute, Mount Zion Hospital and Medical Center, San Francisco, California 94120

The incidence of tumors induced by a single s.c. injection of 2 mg of 3-methylcholanthrene was observed in euthyroid and thyroidectomized rats and in rats fed thyroid powder. Thyroid feeding increased the metabolic rate by a factor of 1.6 and reduced the incidence of tumors at the site of injection from 92% in euthyroid rats to 36% in hyperthyroid rats.

¹ This work was supported in part by USPHS General Research Support Grant RR 05472.

Received 10/28/74. Accepted 11/11/74.

This article has been cited by other articles:

				C. A. Gorman, D. V. Becker, F. S. Greenspan, R. P. Levy, J. H. Oppenheimer, R. S. Rivlin, J. Robbins, and W. P. VanderLaan Breast Cancer and Thyroid Therapy: Statement by the American Thyroid Association JAMA, April 4, 1977; 237(14): 1459 - 1460. [Abstract] [PDF]

				EDUCATION COMMITTEE, AMERICAN THYROID ASSOCIATION, C. A. GORMAN, D. V. BECKER, F. S. GREENSPAN, R. P. LEVY, J. H. OPPENHEIMER, R. S. RIVLIN, J. ROBBINS, and W. P. VANDERLAAN American Thyroid Association Statement: Breast Cancer and Thyroid Hormone Therapy Ann Intern Med, April 1, 1977; 86(4): 502 - 503. [Abstract] [PDF]