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The Influence of Thyroid Stimulation on the Incidence of 3-Methylcholanthrene-induced Tumors¹

Claire Zellerbach Saroni Tumor Institute, Mount Zion Hospital and Medical Center, San Francisco, California 94120

The incidence of tumors induced by a single s.c. injection of 2 mg of 3-methylcholanthrene was observed in euthyroid and thyroidectomized rats and in rats fed thyroid powder. Thyroid feeding increased the metabolic rate by a factor of 1.6 and reduced the incidence of tumors at the site of injection from 92% in euthyroid rats to 36% in hyperthyroid rats.

¹ This work was supported in part by USPHS General Research Support Grant RR 05472.

Received 10/28/74. Accepted 11/11/74.