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The Glycosaminoglycans in Human Hepatic Cancer

Department of Medicine, The Center for Adult Diseases, Osaka, 3 Nakamichi 1-chome Higashinari-ku, Osaka 537, Japan

A method is proposed for the analysis of glycosaminoglycans that were isolated from human liver, combining cellulose acetate electrophoresis and enzymatic digestion with mucopolysaccharidases.

The major constituent of glycosaminoglycans in the healthy liver is heparan sulfate and/or heparin (about 65%), with approximately equal quantities of dermatan sulfate and hyaluronic acid (about 13.5 and 13%, respectively) and a small amount of chondroitin sulfate. These components, especially chondroitin sulfate and hyaluronic acid, are markedly increased in hepatic carcinomas.

Received 4/ 9/74. Accepted 10/22/74.

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