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Blastomogenic Activity of p-Hydroxyphenyllactic Acid in Mice

Laboratory of System Blood Diseases and Division of Pathological Anatomy, Institute of Experimental and Clinical Oncology, Kashirskoye Shosse, 6, Moscow V-409, U. S. S. R.

Blastomogenic activity of p-hydroxyphenyllactic acid was established by prolonged s.c. administration into C57BL/6 and CC57BR mice. Phenyllactic acid was also tested and was not blastomogenic under the same conditions. The preparations in aqueous solutions were injected into the dorsal region twice weekly in 2.5-mg doses. The total dose per mouse was 42 mg p-hydroxyphenyllactic acid or 50 mg phenyllactic acid.

The resorptive character and many forms of blastomogenic activity of p-hydroxyphenyllactic acid were shown. It induced neoplasms of varied histogenesis (leukemias, adenomas, hepatomas, and tumors of the vascular tissue), including benign and malignant tumors and precancerous conditions of the urinary bladder.

Received 11/ 2/73. Accepted 11/ 4/74.