This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hosokawa, M. Articles by Pressman, D. Search for Related Content PubMed PubMed Citation Articles by Hosokawa, M. Articles by Pressman, D.

Effect of Antimyeloma Cell Antiserum on Immunological Enhancement¹

Department of Experimental Therapeutics and Grace Cancer Drug Center [M. H., E. M.], and Department of Immunology and Immunology Research [T. W., D. P.], Roswell Park Memorial Institute, New York State Department of Health, Buffalo, New York 14203

Growth of Sarcoma 180 in AKR mice was enhanced by immunization with frozen-thawed homogenates of this tumor. Treatment of host mice with rabbit antimyeloma cell antiserum, either during immunization or shortly after tumor implantation, resulted in a decreased incidence of tumor rejection or an increased rate of tumor growth. A slowg-growing subline from a spontaneous DBA/2Ha-DD mammary tumor is rejected after initial growth in DBA/2J mice. The incidence of rejection was reduced by treatment with the antiserum studied.

¹ This work was supported in part by USPHS Grants CA-13038 and CA-14562.

² On leave from the Department of Pathology, Cancer Institute, Hokkaido University School of Medicine, Sapporo, Japan. The work reported in this paper was undertaken during the tenure of a Research Training Fellowship awarded by the International Agency for Research on Cancer.

³ Present address: The Third Department of Internal Medicine, Osaka University Hospital, Osaka, Japan.

Received 9/ 6/74. Accepted 11/21/74.