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Effect of Core Lipopolysaccharides from Salmonella minnesota R Mutants on the Survival Times of Mice Bearing Ehrlich Tumor¹

Laboratoire de Recherche, Institut du Cancer de Montréal, Hôpital Notre Dame, Montréal, Quebec, Canada

Injection of a homologous series of bacterial core lipopolysaccharides obtained from Salmonella minnesota R mutants to Ehrlich solid tumor-bearing mice results in an increase of survival times of treated animals. Lower chain length favors greater antitumor activity. Oligosaccharides and polysaccharides derived from lipopolysaccharides were found to be ineffective in increasing survival time of tumor-bearing mice. Smaller-sugar-chain-length core lipopolysaccharides were found to be better adjuvant than were those with longer sugar chains. Implication of adjuvant action of lipopolysaccharides in the elicitation of antitumor activity is suggested.

¹ Supported by Grants from the National Cancer Institute of Canada.

² Research Associate of the National Cancer Institute of Canada. Present address: Département de Biologie Cellulaire, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, Quebec, Canada.

Received 3/ 8/73. Accepted 11/27/74.