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Graft versus Leukemia without Fatal Graft-versus-Host Disease in AKR Mice¹

Division of Clinical Hematology, Department of Medicine [S. J. C., M. M. A.], and Department of Pathology [A. R. E.], Rhode Island Hospital, Providence, Rhode Island 02902

BW 5147 leukemia in AKR mice has been successfully treated by adoptive immunotherapy using allogeneic spleen cells from C57BL/6J mice. Graft-versus-host reaction was prevented by treatment with spleen cells from a second allogeneic strain (CBA, H-2 identical with AKR), followed by cyclophosphamide and syngeneic spleen cells. Successful treatment of leukemia without graft-versus-host reaction is dependent upon a close relationship at the H-2 locus between the second allogeneic donor and the host AKR mice, since cells from a non-H-2 identical donor (DBA/2) do not increase survival. The doses of cyclophosphamide and of C57BL/6J spleen cells are also parameters of critical importance in successful treatment.

¹ Second article of a series. This research was supported in part by the George V. Meehan Fund-Clinical Research in Blood Diseases, The Phyllis Kimball Johnstone and H. Earle Kimball Foundation, and the Louis and Goldie Chester Memorial Fund.

Received 6/ 3/74. Accepted 11/18/74.