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Investigation of the Possible Involvement of Ketonic Derivatives of Polycyclic Hydrocarbons in Hydrocarbon Carcinogenesis¹

Chester Beatty Research Institute, Institute of Cancer Research, Royal Cancer Hospital, Fulham Road, London, SW3 6JB [A. D., L. S. L.], and Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, England [P. T. I.]

5,6-Dihydro-5-oxo-7,12-dimethylbenz[a]anthracene and 5,6-dihydro-6-oxo-7,12-dimethylbenz[a]anthracene are described. These compounds, which are isomeric with 7,12-dimethylbenz[a]anthracene-5,6-oxide (the K-region epoxide), were inactive in tests for tumor-initiating activity in mouse skin and tumor production in the s.c. tissue of the mouse.

¹ This work was supported by grants to the Chester Beatty Research Institute and the Paterson Laboratories from the Medical Research Council and the Cancer Research Campaign.

Received 9/16/74. Accepted 12/ 6/74.

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