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Effect of Water-soluble Adjuvants on in Vitro Lymphocyte Immunization¹

Departments of Surgery [B. S., P. I. T.], Biomathematics [M. R. M.], and Medicine [O. K.], School of Medicine, University of California, Los Angeles, California 90024

Water-soluble adjuvants prepared from Mycobacterium smegmatis and human mixed mycobacteria strains C, DT, and PN were found to increase lymphocyte response in one-way mixed-lymphocyte culture and in vitro immunization to cultured human tumor cells. Phytohemagglutinin-induced lymphocyte blastogenesis, however, was depressed by water-soluble adjuvants.

¹ This work was supported by Contract N01 CP 43933 from the National Cancer Institute.

Received 8/13/74. Accepted 11/20/74.