This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Marks, D. B. Articles by Marks, A. D. Search for Related Content PubMed PubMed Citation Articles by Marks, D. B. Articles by Marks, A. D.

The Presence of Histone H1° in Human Tissues¹

Departments of Biochemistry [D. B. M., T. K., and B. J. K.] and Medicine [A. D. M.] Temple University School of Medicine, Philadelphia, Pennsylvania 19140

Histone H1° was found to be present in a number of human tissues. It constituted 50% of the total 5% perchloric acid-soluble histone in human breast, 35% in thyroid, 12 to 18% in adrenal, and 7% in parathyroid tissues. The quantities of histone H1° in these human tissues were large compared with the amounts found in rat liver (8%), calf thymus (0%), and HeLa cells (0%).

Although the quantity of histone H1° was found to vary from one type of tissue to another, it was essentially constant in normal, hyperplastic, and neoplastic human thyroid tissues.

¹ This work was supported by USPHS Grant GM 18843 and Institutional Grant IN88E to Temple University from the American Cancer Society.

² Present address: Presbyterian-University Hospital, Pittsburgh, Pa.

Received 9/17/74. Accepted 12/19/74.