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Induction of Urinary Bladder Tumors in Rats by Administration of Nitrosomethyldodecylamine¹

Carcinogenesis Program, Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830

Nitrosomethyl-n-dodecylamine, a product of the reaction of dimethyl-n-dodecylamine with nitrous acid, was given to Sprague-Dawley rats by gavage in olive oil solution. Twice-weekly treatments with 12 mg of the nitrosamine for 50 weeks gave rise to 100% incidence of transitional cell carcinomas of the urinary bladder. In contrast with the tests of other N-nitroso compounds, this compound seemed to be more effective in males than in females; females died later with the tumor although the dose per unit body weight was higher in females than in males.

¹ Research jointly supported by the Chemical Carcinogenesis Program of the National Cancer Institute, and by the U. S. Atomic Energy Commission under contract with the Union Carbide Corporation.

Received 9/23/74. Accepted 12/23/74.

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