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Dehydroretronecine-induced Rhabdomyosarcomas in Rats¹

Department of Pathology, University of Wisconsin Medical School, Regional Primate Research Center and Food Research Institute, University of Wisconsin, Madison, Wisconsin 53706

Two groups of rats were given s.c. injections of either monocrotaline or its major detectable metabolite, dehydroretronecine, biweekly for 1 year. Tissues obtained from partial hepatectomies performed at 4 months on a portion of these animals showed that both compounds caused a decided inhibition of mitotic division in regenerating liver. Rhabdomyosarcomas developed at the site of dehydroretronecine injection in 51.6% of the rats and in 3.3% of the monocrotaline-treated rats. Metastatic lesions were recorded in 8.3% of these animals. In addition to the above, 10% of the monocrotaline-treated rats developed other tumors that included myelogenous leukemias, hepatocellular carcinomas, and pulmonary adenomas. These data indicate that either monocrotaline or its metabolite dehydroretronecine are capable of causing neoplastic transformations in the tissues of experimental animals.

¹ This investigation was supported in part by USPHS Grants HL-10941, CA-13288, and RR-00167 from the NIH, and American Cancer Society Institution Research Grant IN-35M-11 to the University of Wisconsin. Primate Center Publication 14-016.

Received 10/30/74. Accepted 1/10/75.

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