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Uptake of ⁶⁷Ga in the Regenerating Rat Liver and Its Relationship to Lysosomal Enzyme Activity¹

Radiopharmacology Department, Institute of Cancer Research, Royal Marsden Hospital, Sutton, Surrey SM2 5PT, England

The uptake of ⁶⁷Ga citrate has been studied in the regenerating rat liver over a period up to 72 hr after partial hepatectomy. The concentration of ⁶⁷Ga was found to be maximal (four times that of controls) 42 hr after hepatectomy. This was shown to be related to lysosomal enzyme activity rather than to specific phases of the cell cycle, there being a highly significant correlation (p < 0.001) with aryl sulfatase activity.

In both regenerating and normal rat livers, it was shown that ⁶⁷Ga uptake is reduced when protein synthesis is inhibited by cycloheximide but is unaffected by inhibition of DNA synthesis by cytosine arabinoside.

¹ We acknowledge the financial assistance of the Vandervell Foundation.

² On sabbatical leave from Monash University, Melbourne, Australia.

Received 11/19/74. Accepted 1/22/75.

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