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Tissue Water Content and Nuclear Magnetic Resonance in Normal and Tumor Tissues

Ion-Christian Kiricuta, Jr.¹ and Virgil Simplceanu

Biophysical Department, Oncological Institute of Cluj, Str. Republici nr. 34–36, Cluj [I. C. K.], and Institute for Atomic Physics, P. O. Box 35, Bucharest [V. S.], Romania

Pulsed proton nuclear magnetic resonance was used to differentiate between normal and malignant tissues.

When the tissue water content varied from 80 to 93%, the tumors exhibited spin-lattice relaxation times (T₁) from 0.9 to 1.8 sec. We report also the results obtained on 9-day-old embryos and on liver, brain, and heart from 2-day-old rats. A good correlation between the spin-lattice (T₁) and spin-spin (T₂) relaxation times and the tissue water content was found for all tissues studied. The relaxation times T₁ and T₂ and water content in Walker 256 carcinoma and its lymph node metastasis were quite similar.

¹ To whom requests for reprints should be addressed.

Received 6/27/74. Accepted 12/11/74.

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