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Delayed Hypersensitivity to 5-Fluorouracil following Topical Chemotherapy of Cutaneous Cancers¹

Departments of Surgery [P. W. A. M., M. S. L., E. T. K.] and Pathology [H. I.], Tulane University Medical School, New Orleans, Louisiana 70112

Skin tests to various common antigens, dinitrochlorobenzene, and 5-fluorouracil (5-FU) were performed on patients being treated for cutaneous neoplasms with topical 5-FU cream. Eleven of 15 patients tested both before and after therapy converted from skin test negative to positive with respect to 5-FU. This conversion correlated with positive dinitrochlorobenzene skin tests and therapeutic cure. The relation between the induction of delayed hypersensitivity reactions to 5-FU following treatment with topical 5-FU and the cure rate for cutaneous neoplasms showed a trend toward correlation.

¹ Supported in part by the Tulane Skin Cancer Research Fund; National Cancer Institute Grants 5-PO2, CA-05837, 5-TO1, CA-05108, and CA-80807; Eustis Fund; and Women's Auxiliary of the VFW.

² Instructor of Surgery.

³ Associate Professor of Surgery.

⁴ Professor of Pathology.

⁵ Professor of Surgery.

Received 8/14/74. Accepted 2/ 7/75.

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