This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Mansell, P. W. A. Articles by Krementz, E. T. Search for Related Content PubMed PubMed Citation Articles by Mansell, P. W. A. Articles by Krementz, E. T.

Delayed Hypersensitivity to 5-Fluorouracil following Topical Chemotherapy of Cutaneous Cancers¹

Departments of Surgery [P. W. A. M., M. S. L., E. T. K.] and Pathology [H. I.], Tulane University Medical School, New Orleans, Louisiana 70112

Skin tests to various common antigens, dinitrochlorobenzene, and 5-fluorouracil (5-FU) were performed on patients being treated for cutaneous neoplasms with topical 5-FU cream. Eleven of 15 patients tested both before and after therapy converted from skin test negative to positive with respect to 5-FU. This conversion correlated with positive dinitrochlorobenzene skin tests and therapeutic cure. The relation between the induction of delayed hypersensitivity reactions to 5-FU following treatment with topical 5-FU and the cure rate for cutaneous neoplasms showed a trend toward correlation.

¹ Supported in part by the Tulane Skin Cancer Research Fund; National Cancer Institute Grants 5-PO2, CA-05837, 5-TO1, CA-05108, and CA-80807; Eustis Fund; and Women's Auxiliary of the VFW.

² Instructor of Surgery.

³ Associate Professor of Surgery.

⁴ Professor of Pathology.

⁵ Professor of Surgery.

Received 8/14/74. Accepted 2/ 7/75.