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Localization of Polycyclic Hydrocarbon Carcinogens in the Lung following Intratracheal Instillation in Gelatin Solution¹

Department of Physiology, Harvard School of Public Health, Boston, Massachusetts 02115

The deposition and localization of benzo(a)pyrene (BP) suspended in a gelatin-0.9% NaCl solution was studied in hamster lungs by ultraviolet fluorescence microscopy. BP was deposited primarily in the alveolar region of the lung. Although large numbers of BP-filled macrophages were seen in the upper airways by 24 hr after an instillation, little BP appeared to penetrate into the bronchial epithelium. The intratracheal instillation of polycyclic hydrocarbons in a gelatin-0.9% NaCl solution appears to be a useful model when it is desired to deliver the carcinogen dose to the peripheral lung.

¹ This research was supported by National Cancer Institute Contract CP 33273 and National Institute of Environmental Health Sciences Grant ES-00002.

Received 11/ 5/74. Accepted 3/ 6/75.

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