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Absence of Specificity in Inhibition of DNA Repair Replication by DNA-binding Agents, Cocarcinogens, and Steroids in Human Cells¹

Laboratory of Radiobiology, University of California, San Francisco, California 94143

Although many chemicals, including cocarcinogens, DNA-binding agents, and steroids, inhibit repair replication of ultraviolet-induced damage to DNA in human lymphocytes and proliferating cells in culture, none of these chemicals is specific. Our results show that all the chemicals we tested inhibit normal DNA synthesis as much as or more than they inhibit repair replication. There is thus no evidence in our results to support the hypothesis that cocarcinogens are specific inhibitors of DNA repair or that any of the chemicals studied might be useful adjuncts to tumor therapy merely because of specific inhibition of radiation repair mechanisms.

¹ This study performed under the auspices of the United States Atomic Energy Commission.

Received 12/16/74. Accepted 4/ 3/75.

This article has been cited by other articles:

				N. J. Bernheim and H. Falk Dr. Chemical, Physical, and Genetic Factors Interfering with DNA Repair-a Review International Journal of Toxicology, May 1, 1983; 2(3): 23 - 54. [Abstract] [PDF]