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Amino Acid and Sugar Transport in Cells Permissively Infected with Simian Virus 40¹

Department of Therapeutic Radiology, Division of Radiobiology, Tufts-New England Medical Center, Boston, Massachusetts 02111

Transport of -aminoisobutyric acid and 2-deoxy-D-glucose in African green monkey kidney cells was measured 8 to 100 hr following permissive simian virus 40 infection. No differences in transport were detected during the time-period studies, and no significant differences were seen between the apparent Michaelis-Menten constants of normal and virally infected cells. The absence of transport enhancement in permissive simian virus 40 infection suggests that the augmented transport of viral-transformed cell lines devolves upon altered host genome function.

¹ This work was partly supported by USPHS Grant CA13252 and Tufts-New England Medical Center Grant 84750.

² Present address: Director of Emergency Services, Central Emergency Hospital, Afula, Israel. Recipient of NIH Postdoctoral Fellowship 1F22 CA00883-01 which partly supported this work.

³ Recipient of NIH Postdoctoral Fellowship IF22 CA00528-01 which partly supported this work.

⁴ Recipient of American Cancer Society Award PRA-78 which partly supported this work.

Received 11/14/74. Accepted 4/ 1/75.