This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Chan, J. C. Articles by Dmochowski, L. Search for Related Content PubMed PubMed Citation Articles by Chan, J. C. Articles by Dmochowski, L.

Alteration of the Syncytium-forming Property of XC Cells by Productive Moloney Leukemia Virus Infection¹

Department of Virology, The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Texas Medical Center, Houston, Texas 77025

The effect of productive murine leukemia virus (MuLV) infection on the syncytium-forming property of XC cells was studied. MuLV-Moloney-infected XC cells, designated XC(M), initially went through a period of spontaneous syncytium formation. The syncytia then disappeared, and XC(M) cells continued to propagate and produce both infectious MuLV and MuLV group-specific antigens. However, XC(M) cells became refractory to syncytium formation that was induced by Kirsten, Friend, Rauscher, and Moloney strains of murine oncornaviruses. These data suggest that XC(M) cells lost their syncytium-forming ability as a result of productive MuLV infection.

¹ This study was supported in part by Contract NO1-CP-33304 within the Virus Cancer Program of the National Cancer Institute; by Grants CA-05831 and RR-05511 from the National Cancer Institute, NIH, USPHS; and by Grant ACS IN-43N from the American Cancer Society, Inc.

Received 2/20/75. Accepted 4/ 7/75.