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Localization of the ß Chain of Human Chorionic Gonadotropin on Human Tumor Cells and Placental Cells¹

Division of Perinatal Medicine, Departments of Pediatrics, Obstetrics-Gynecology [M. A. N., D. A. M., E. B., M. J. W.], and Pathology [L. M. M., L. M. F., A. M.], University of Colorado Medical Center, Denver, Colorado 80220

With the use of peroxidase-labeled antibody to the ß chain of human chorionic gonadotropin, sections of ten human malignant tumors were found to react with this antibody. It is postulated that both selective host immunosuppression by tumors and selective maternal immunosuppression by fetal tissues may be mediated by human chorionic gonadotropin.

¹ This work was supported by Milheim Foundation for Cancer Research Grant 74-37, Program Project in Basic Oncology Grant 1-P01-CA-13419-01, USPHS Grant HD-00781, National Cancer Institute Grants CA-15823 and CA-15109, and American Cancer Society Grant BC189.

² To whom requests for reprint should be addressed, at 4200 E. Ninth Ave., Denver, Colo. 80220.

Received 2/28/75. Accepted 4/22/75.