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Carcinogenicity of Nitrosation Products of Ephedrine, Sarcosine, Folic Acid, and Creatinine¹

Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Carcinogenic activity of several synthetic N-nitroso compounds was evaluated in C57BL/6J x C3HeB/FeJ F₁ mice. Test substances, suspended in trioctanoin, were injected i.p. in three equal doses given on Days 1, 4, and 7 after birth and animals were held without further treatment for up to 85 weeks.

Nitrosoephedrine at a total dose of 600 mg/kg induced metastasizing liver cell carcinomas in 28 of 30 animals. Nitrososarcosine (225 mg/kg) induced similar tumors in 8 of 14 animals. Nitrosofolic acid (375 mg/kg) induced lung adenocarcinomas in 4 of 28 mice. Creatinine-5-oxime (600 mg/kg) showed no evidence of carcinogenic activity. Diethylnitrosamine (12 mg/kg given in four doses), included as a positive control, caused metastasizing liver cell tumors in 23 of 25 animals.

¹ Financial support was provided by Grant 5 PO1 ES 00597 from National Institute of Environmental Health Sciences, NIH.

² To whom requests for reprints should be sent, at Massachusetts Institute of Technology, Building 56, Room 217, Cambridge, Mass. 02139.

Received 1/31/75. Accepted 4/18/75.

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