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Tumor-selective Inhibition of the Incorporation of ³H-Labeled Amino Acids into Protein by Cyanate¹

Department of Biochemistry, College of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey 07103 [M. A. L., M. R. K], and Department of Biochemistry, Howard University College of Medicine, Washington, D.C. 20001 [H. P. M]

Sodium cyanate at a dose level of 125 or 250 mg/kg i.p. caused an inhibition of incorporation of ³H-labeled amino acids into cytoplasmic and nuclear proteins of the rapidly growing hepatoma 7777 and the slowly growing hepatoma 9618A. There was no inhibitory effect on ³H-labeled amino acid incorporation into protein in the livers of rats bearing these tumors. Studies on the effects of sodium cyanate on incorporation of ³H-labeled amino acids into total acidinsoluble material indicated that a greater than 85% inhibition could be achieved in hepatoma 5123C, hepatoma 9618A₂, and the MK3 kidney tumor with either little or no effect in host liver, kidneys, brain, skeletal muscle, intestinal mucosa, and regenerating liver after partial hepatectomy.

¹ This work was supported in part by Grants CA-10729, CA-12933, and CA-16274 from the USPHS, National Cancer Institute.

Received 3/12/75. Accepted 5/13/75.