This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by McDonald, J. J. Articles by Brown, G. B. Search for Related Content PubMed PubMed Citation Articles by McDonald, J. J. Articles by Brown, G. B.

Conversion of the Oncogenic 1-Methylguanine 3-Oxide to 3-Hydroxy-1-methylxanthine¹

Memorial Sloan-Kettering Cancer Center, New York, New York 10021

Deamination of the oncogenic 1-methylguanine 3-oxide occurs to a significant extent in rats to yield 3-hydroxy-1-methylxanthine and its metabolites. When 3-hydroxy-1-methylxanthine is administered, 1-methyl-8-methylthioxanthine can be recovered from urine and released from hepatic protein. No 1-methyl-8-methylthioguanine was detected in urine or bound to protein. There is no evidence of significant activation of 1-methylguanine 3-oxide by sulfotransferase, but deamination to the oncogenic 3-hydroxy-1-methylxanthine suffices to explain its oncogenicity.

¹ This investigation was supported in part by USPHS Research Grants CA-15274, CA-17085, and CA-08748 from the National Cancer Institute. Results included here were presented in part at the 66th Annual Meeting of the American Association for Cancer Research, San Diego, Calif., May 1975 (9). This paper is Contribution 64 in a series on purine N-oxides.

² To whom requests for reprints should be sent.

Received 1/19/76. Accepted 6/14/76.