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Immunization against Feline Oncornavirus Disease Using a Killed Tumor Cell Vaccine¹

Department of Veterinary Pathobiology, The Ohio State University, Columbus, Ohio 43210

Specific pathogen-free cats were immunized with an inactivated feline oncornavirus tumor cell vaccine. Immunized cats produced high antibody titers to the feline oncornavirus-associated cell membrane antigen and were protected from oncogenic feline sarcoma virus challenge. However, immunization did not produce virus-neutralizing antibody nor did it prevent viremia.

¹ This study was conducted under Contract N01 CP 53571 within the Virus Cancer Program of the National Cancer Institute, NIH, USPHS.

Received 2/ 9/76. Accepted 6/30/76.

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