This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Castle, M. C. Articles by Oliverio, V. T. Search for Related Content PubMed PubMed Citation Articles by Castle, M. C. Articles by Oliverio, V. T.

Distribution and Excretion of [³H]Vincristine in the Rat and the Dog

Office of the Associate Director for Experimental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20014

The distribution and excretion of tritiated vincristine were studied in the rat and the dog. Biphasic curves for the disappearance of the drug from blood were found in both species, with an initial half-life of approximately 15 min and a secondary half-life of approximately 75 min. Tissue levels were high at 1 hr in the rat and declined rapidly, except in the brain where very low levels of drug were found at all times. The bile was found to be the major route of excretion. The peak rate of excretion in bile was found to occur earlier in the rat (10 min) than in the dog (60 min). Rats given a higher dose of vincristine (1.0 mg/kg) excreted a larger percentage of the dose in the bile than rats given a lower dose (0.1 mg/kg). In rats given a low dose of vincristine (0.1 mg/kg), more than 85% of the drug was excreted in the feces and the urine over 72 hr. Less than 10% of the total radioactivity in the bile and urine was metabolites whereas, in the plasma, metabolites accounted for 40% of the total radioactivity.

Received 9/24/75. Accepted 6/21/76.

This article has been cited by other articles:

				K. Kai, H. Sahto, M. Yoshida, T. Suzuki, Y. Shikanai, T. Kajimura, and K. Furuhama Species and Sex Differences in Susceptibility to Olfactory Lesions Among the Mouse, Rat and Monkey Following an Intravenous Injection of Vincristine Sulphate Toxicol Pathol, April 1, 2006; 34(3): 223 - 231. [Abstract] [Full Text] [PDF]

				F. M. Boyle, S. L. Eller, and S. A. Grossman Penetration of intra-arterially administered vincristine in experimental brain tumor Neuro-oncol, October 1, 2004; 6(4): 300 - 306. [Abstract] [PDF]

				K. D. Tanner, D. B. Reichling, and J. D. Levine Nociceptor Hyper-Responsiveness during Vincristine-Induced Painful Peripheral Neuropathy in the Rat J. Neurosci., August 15, 1998; 18(16): 6480 - 6491. [Abstract] [Full Text] [PDF]