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Cell Surface Changes in HeLa Cells as an Indication of Cell Cycle Events¹

Department of Pathology, University of Umeå, S-901 87 Umeå, Sweden

A HeLa cell line synchronized by double thymidine block and mitotic shake off was shown to have a characteristic surface morphology for each of the different cell cycle stages. Inhibitors of cell multiplication were used to arrest cells in specific cell cycle phases, and these cells had a surface morphology similar to that of synchronized cells in the same phase. The results indicated a close association between the cell surface topography and the cycles of DNA synthesis in the cell nucleus of this HeLa line.

¹ This investigation was supported by grants from the Swedish Cancer Society, Project 659-B74-02X, and from the Medical Faculty, University of Umeå.

Received 2/18/75. Accepted 7/ 2/76.