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Cell Lines Derived from Teratocarcinomas¹

Service de Génétique Cellulaire de l'Institut Pasteur et du Collège de France, 25 rue du Dr. Roux, 75015 Paris, France

A variety of cell lines have been isolated in vitro from transplantable teratocarcinomas. Some of them correspond to embryonal carcinoma (EC) cells. They are malignant and represent the stem cells from which all differentiated tissues derive in the tumor or in vitro. EC cells share some biochemical and antigenic properties with multipotential embryonic cells.

From one of these EC cell lines, variants have been isolated in vivo and in vitro. Some are of EC type but restricted in their pattern of differentiation; others are altered in their tumorigenicity or in their antigenic characteristics. Another class of such variants corresponds to non-EC types. The most interesting ones correspond to tumoral lines of extraembryonic tissues.

All these cell lines constitute a valuable material for the study of mouse development and differentiation.

¹ Presented at the Conference, "Regulation of Gene Expression in Development and Neoplasia," June 2 to 5, 1976, Santa Ynez, Calif. This work was supported by grants from the NIH (Grant 1 R 01.CA.16355.01), the André Meyer Foundation, the Centre National de la Recherche Scientifique (LA 88), the Délégation Généale à la Recherche Scientifique et Technique (73.7.1208), and the Fondation del Duca.

² Presenter. To whom correspondence should be addressed.

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