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Genes Responsible for Transformation by Avian RNA Tumor Viruses¹

Department of Molecular Biology and Microbiology and Cancer Research Center, Tufts University School of Medicine, Boston, Massachusetts 02111

Avian sarcoma viruses probably contain 4 genes. One of these, src, controls the process of transformation of the infected cell and has been located near the 3' end of the viral genome. The remaining 3 genes direct the synthesis of virion proteins: env (envelope proteins), pol (polymerase), and gag (internal proteins). They are probably in the order gag-poly-env-src. A scheme for the replication of these viruses is proposed, and several possible mechanisms for their origin and variability are discussed.

¹ Presented at the Conference, "Regulation of Gene Expression in Development and Neoplasia," June 2 to 5, 1976, Santa Ynez, Calif. Work in my laboratory is supported by Grants CA 12924 and CA 17659 from the National Cancer Institute and VC-184 from the American Cancer Society.