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Electronic Volume Analysis of L1210 Chemotherapy¹

Papanicolaou Cancer Research Institute, Miami, Florida 33123

The rapid analysis of in vivo chemotherapy on the L1210 ascites tumor grown in C57BL/6 x DBA/2 F₁ mice has been shown by means of an electronic volume analysis. The drugs were injected on the 4th day of tumor growth, and the cells in the peritoneal cavity were studied at 24-hr intervals on the 5th through 7th day. Using the electronic cell volume distributions, combined with labeling indices, cell morphology, and cell counts, it was found that the alkylating agents, 1,3-bis(2-chloroethyl)-1-nitrosourea and cyclophosphamide, at the dosages used, were more effective than the S-phase-specific drugs, palmitoyl ester of 1-ß-D-arabinofuranosylcytosine, vincristine, and methotrexate.

¹ This work was supported in part by Grant NO1 CB33861 from the National Cancer Institute and Contract RO1CA 14774 from the NIH.

Received 1/26/76. Accepted 8/23/76.