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Glycopeptides from the Surface of Human Neuroblastoma Cells¹

Department of Pediatrics, University of Pennsylvania Medical School, and the Joseph Stokes Research Institute, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104

Glycopeptides suggesting a complex oligosaccharide composition are present on the surface of cells from human neuroblastoma tumors and several cell lines derived from the tumors. The glycopeptides, labeled with radioactive L-fucose, were removed from the cell surface with trypsin, digested with Pronase, and examined by chromatography on Sephadex G-50. Human skin fibroblasts, brain cells, and a fibroblast line derived from neuroblastoma tumor tissue show less complex glycopeptides. Although some differences exist between the cell lines and the primary tumor cells, the similarities between these human tumors and animal tumors examined previously are striking.

¹ This investigation was supported by American Cancer Society Grants PRA-68 and BC-109 and by USPHS Grants CA 14037 and CA 14489.

Received 6/28/76. Accepted 9/ 7/76.