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Evaluation of the Mutagenicity of Compounds of Known Carcinogenicity, Belonging to the Benz[a]anthracene, Chrysene, and Cyclopenta[a]phenanthrene Series, Using Ames's Test

Departments of Cell Regulation [C. D.] and Chemistry [M. M. C, A-M. K.], Imperial Cancer Research Fund Laboratories, Lincoln's Inn Fields, London WC2A 3PX, England

Fifty-four polycyclic compounds, 29 of the cyclopenta[a]phenanthrene series, 11 chrysenes, and 14 benz[a]anthracenes, have been tested for mutagenicity by Ames's method, using Salmonella typhimurium TA100. Without exception all 37 carcinogens and a known initiator were mutagens. Of the 16 noncarcinogens 7 were mutagenic, but none of these has yet been tested for initiating, as opposed to carcinogenic, activity. There appeared to be little quantitative correspondence between carcinogenic and mutagenic potency, however, and possible reasons for this are discussed. The aryl hydrocarbon hydroxylase inhibitor 7,8-benzoflavone strongly inhibited the mutagenicity of certain compounds when it was added to the incubations.

Received 6/ 8/76. Accepted 8/30/76.

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