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-Fetoprotein in Toxic Liver Injury1
The Joseph Gottstein Memorial Cancer Research Laboratory, Department of Pathology, University of Washington, Seattle, Washington 98195 [E. A. S., M. K.], and the Department of Pathology, University of California, San Diego Campus, La Jolla, California 92037 [S. S.]
The temporal sequence of
-fetoprotein appearance in serum was determined in both necrogenic and nonnecrogenic liver injury. Ethionine, thioacetamide, and CCI4 were used to intoxicate male and female rats for evaluating serum enzyme levels, mitotic indices, and morphological reflections of impairment. Thioacetamide- and CCI4-induced cell death preceded the mitotic wave in residual hepatocytes, and, in the case of both agents, this intoxicant-mediated necrosis preceded the emergence of
-fetoprotein. Yet, although there was no evidence of either cell destruction or significant mitotic activity in ethionine-poisoned animals, serum
-fetoprotein levels progressively increased. Thus the temporal sequence of
-fetoprotein synthesis and/or release and cellular reorganization for regeneration suggests that reappearance of the protein macromolecule is an expression of the altered phenotype observed during the "step-down" phase of liver regeneration.
1 Supported in part by USPHS Grants AM 08686 and CA 13600 and by Contract CP-33403-31.
2 Present address: Department of Pathology, University of California School of Medicine, San Francisco, Calif. 94143. To whom requests for reprints should be addressed.
Received 5/12/76. Accepted 9/10/76.
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