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Long-Term Transplantability and Morphological Stability of Three Experimentally Induced Urinary Bladder Carcinomas in Rats¹

Division of Immunology, Fred Hutchinson Cancer Research Center, Seattle 98104 [T. W., K. E. H.], and Departments of Urology [W. H. C.] and Pathology [K. E. H.], University of Washington Medical School, Seattle, Washington 98195

Three transitional cell carcinomas induced in Fischer 344 rats by a methylcholanthrene pellet or a foreign body inserted locally into the bladder have been serially transplanted in the syngeneic strain for up to 6.5 years. There have been no changes in the individual morphological characteristics of the tumors during this time. Cells cultured in vitro for varying numbers of passages reproduce regularly the morphology of each tumor when they are injected back into the animals, and results from a microcytotoxicity assay for cellular immunity indicate that they retain a common, bladder tumor-specific antigen. These tumors are useful for research in tumor biology and are offered to other scientists seeking transplantable carcinomas for experimentation.

¹ This study was supported by NIH Grants CA-14135 and CA-3842.

² To whom requests for reprints should be addressed, at the Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, Wash. 98104.

Received 2/12/76. Accepted 9/10/76.