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Distribution of [³H]-3-Hydroxykynurenine in Mice¹

Department of Medical Chemistry, National Institute of Hygienic Sciences, Kamiyoga 1-chome, Setagaya-ku, Tokyo 158, Japan

The distribution of 3-hydroxykynurenine, a tryptophan metabolite that is suspected of being carcinogenic, was studied in mice. After s.c. administration of [³H]-3-hydroxykynurenine into male BALB/c x DBA/2 F₁ mice, the distribution of ³H was investigated by whole-body autoradiography and radioactivity measurement. At 30 and 60 min after injection, ³H was distributed mainly in the kidneys, pancreas, liver, lung, and salivary glands. After 6 and 24 hr, ³H was retained only in the kidneys.

After 30 min, about 70% of the radioactive compounds in the pancreas was unmetabolized 3-hydroxykynurenine, whereas most of the radioactivity in the kidneys, liver, lung, and submaxillary glands was derived from the other compounds. The data suggest that 3-hydroxykynurenine has an affinity for the pancreas.

¹ This investigation was supported by Grant-in-Aid for Scientific Research 901029 from the Ministry of Education of Japan.

Received 4/24/75. Accepted 9/22/75.