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Hyperprolactinemia and Steroid Metabolism by Rat Mammary Adenocarcinomas¹

Department of Clinical Surgery, University Medical School, Edinburgh EH8 9AG, Scotland

The metabolism of both testosterone and dehydroepian-drosterone by 10 adenocarcinomas induced and grown in the presence of high prolactin (plasma prolactin > 220 ng/ml) was compared with the metabolism of 10 adenocarcinomas induced and grown in the presence of normal levels (plasma prolactin < 60 ng/ml). The tumors associated with high prolactin significantly metabolized more testosterone to both 5-dihydrotestosterone and 5-androstanediol. The metabolism of dehydroepiandrosterone was similar in both groups of tumors. It is concluded that prolactin may differentially influence the metabolism of C₁₉ steroids by rat mammary adenocarcinomas.

¹ This work was performed with a grant from the Cancer Research Campaign, Grant SP 1256.

Received 3/24/75. Accepted 10/20/75.