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DNA-attacking Ability of Carcinogenic Mycotoxins in Recombination-deficient Mutant Cells of Bacillus subtilis¹

Laboratory of Microbial Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Shinjuku-ku, Tokyo 162, Japan

Thirty mycotoxins and 5 chemically modified toxins were tested for DNA-attacking ability in the rec assay using the recombination-deficient mutant of Bacillus subtilis M45 (rec^-) and the parent strain H17 (rec⁺).

Six Penicillium toxins (citrinin, penicillic acid, patulin, (-)-luteoskyrin, (+)-rugulosin, and PR-toxin), 5 Aspergillus toxins (aflatoxins B₁ and G₁, sterigmatocystin, O-acetylsterigmatocystin, and O-acetyldihydrosterigmatocystin), and 2 Fusarium toxins (zearalenone and zearalenol-b) were positive. Among these 13 compounds, the following 8 mycotoxins have been reported to be carcinogenic in animals: citrinin, penicillic acid, patulin, (-)-luteoskyrin, (+)-rugulosin, aflatoxins B₁, and G₁, sterigmatocystin.

Correlation between the rec effect and in vivo carcinogenicity of mycotoxins is discussed.

¹ This work was supported by a grant-in-aid from the Ministry of Education and the Shimabara Science Foundation for 1974.

Received 7/21/75. Accepted 10/14/75.