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Effect of Anti-₁-Fetoprotein on ₁-Fetoprotein-producing Rat Tumors in Vivo and in Vitro

Department of Pathology, University of California of San Diego, Medical School, La Jolla, California 92093

Active or passive immunization of rats to ₁-fetoprotein (AFP) does not consistently inhibit the growth of AFP-producing transplantable hepatomas in vivo, and anti-AFP does not kill these hepatomas in vitro. However, 3 of 14 rats in 1 experiment responded to passive immunization by reversal of tumor growth as evidenced by normalization of elevated AFP serum concentrations, and 1 of 9 rats actively immunized with rat AFP in complete Freund's adjuvant had suppressed growth of transplantable hepatoma 7777.

¹ Supported by NIH Contract NO-1-CP-33403-3 from the National Cancer Institute.

Received 8/ 6/75. Accepted 10/31/75.