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The Epidemiology and Virology of C-type Virus-associated Hematological Cancers and Related Diseases in Wild Mice¹

Department of Pathology [M. B. G., B. E. H., R. W. R.] and Community Medicine [M. P., J. C.], University of Southern California School of Medicine, Los Angeles, California 90033, and Viral Carcinogenesis Branch [J. D. E., R. J. H.], National Cancer Institute, Bethesda, Maryland 20014

In several different populations of wild mice, observed over a 35-month period in laboratory geriatric colonies, a direct correlation was found between the prevalence and titer of spleen complement-fixing gs (p30) antigen and C-type particles in newly trapped healthy mice and a predilection to lymphoma and a hind leg paralytic disease upon aging. Other studies have established the indigenous C-type virus as the essential etiological determinant of both diseases in wild mice. An increased incidence of breast carcinomas, hepatomas, and pulmonary adenomas associated with C-type virus also occurred in the lymphoma-paralysis-prone colony as compared with the tumor-resistant colonies.

¹ Presented at the symposium "Immunological Control of Virus-associated Tumors in Man: Prospects and Problems," April 7 to 9, 1975, Bethesda, Md. Supported by USPHS Contract PH-43-NCl-68-1030 within the Virus-Cancer Program of the National Cancer Institute.

² Presenter.

³ The research described in this report involved animals maintained in animal care facilities fully accredited by the American Association for Accreditation of Laboratory Animal Care.