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Preventive Vaccination against Herpesvirus saimiri-induced Neoplasia¹

Primate Virus Section, Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland 20014

² Presenter. To whom requests of reprints should be addressed at: National Cancer Institute, Frederick Cancer Research Center, Building 538, Fort Detrick, Frederick, Md. 21701.

In this paper we discuss the use of Herpesvirus saimiri as a model for the development of vaccines against herpesvirus-induced neoplasia in primates. Attempts at protection against the oncogenicity of H. saimiri have centered on the inactivation of virus by heat and formalin, the production of temperature-sensitive H. saimiri mutants, and the attenuation of the virus. Each of these approaches has provided information of use in the development of vaccines that may possibly be used in man.

¹ Presented at the symposium "Immunological Control of Virus-associated Tumors in Man: Prospects and Problems," April 7 to 9, 1975, Bethesda, Md.