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Pilot Studies with Human Interferon in Herpesvirus saimiri-induced Lymphoma in Owl Monkeys¹

Department of Virology and Cell Biology, Litton Bionetics, Inc., Kensington, Maryland 20795 [H. R., R. H. N., J. L. C., W. C. W.], and Laboratory of Chemical Pharmacology, National Cancer Institute, Bethesda, Maryland 20014 [R. H. A.]

² Presenter. To whom request for reprints should be addressed.

The nature of Herpesvirus saimiri-induced disease in owl monkeys is described with emphasis on those biological parameters useful in monitoring the disease. These parameters are lymphocyte response to general mitogens, lymphocyte-infective centers, and antibody to virus-associated early antigen. Human interferon was used in treating owl monkeys with virus-induced leukemia. In 2 animals evidence was obtained that suggested a positive antileukemic effect.

¹ Presented at the symposium "Immunological Control of Virus-associated Tumors in Man: Prospects and Problems," April 7 to 9, 1975, Bethesda, Md. Supported in part by Contract N01-CP-53509 within the Virus Cancer Program, National Cancer Institute.