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Murine and Rat Mammary Tumors as Models for the Immunological Study of Human Breast Cancer¹

The Michigan Cancer Foundation, Meyer L. Prentis Cancer Center, Detroit, Michigan 48201

The human breast cancer process and some aspects of experimental mammary cancer are compared in the light of Huxley's hypothesis that each neoplastic cell line may be viewed as a new obligate parasitic species derived from metazoan cells. Sufficient correlations are found to justify the hope that the viral-induced mouse mammary oncogenic process and the carcinogen-induced rat mammary system may serve as reasonable models of the human disease for immunological studies.

¹ Presented at the symposium "Immunological Control of Virus-associated Tumors in Man: Prospects and Problems," April 7 to 9, 1975, Bethesda, Md. Work performed at the Meyer L. Prentis Cancer Center of the Michigan Cancer Foundation, 110 East Warren, Detroit, Mich. 48201, and at the Clinical Cancer Research Laboratory of the Department of Medical Oncology, Wayne State University School of Medicine. Supported by the Michigan Cancer Foundation and by Grant 5 PO2 CA07177-12, and in part by an Institutional Grant from the United Foundation of Greater Detroit.