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Laboratories of Oncology and Cell Biology, Janssen Pharmaceutica Research Laboratories, B-2340 Beerse, Belgium
Ultrastructural investigations on mammalian cells cultured in vitro show that R 17934, a new synthetic anticancer drug, interferes with the structure and function of microtubules, both in interphase and mitotic cells. The activity of this compound in a wide range of experimental tumor systems can thus be explained partly as a direct antimitotic effect and partly as the disintegration of the normal subcellular organization of the nondividing cells. Preliminary investigations in experimental animals show that malignant cells are more susceptible to the antimicrotubular effect of R 17934 than are the nonmalignant cells of the host.
1 This study is supported by a grant from the Institute tot aanmoediging van het wetenschappelijk onderzoek in nijverheid en landbouw, Belgium.
2 To whom requests for reprints should be addressed, at Laboratory of Oncology, Janssen Pharmaceutica, Turnhoutsebaan, 30, B-2340 Beerse, Belgium.
Received 6/16/75. Accepted 10/12/75.
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