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The Influence of Retinyl Acetate on the Postinitiation Phase of Preneoplastic Lung Nodules in Rats¹

Carcinogenesis Program, Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830

The effects of retinyl acetate (RA) on the development of carcinogen-induced metaplastic lung nodules were investigated. Four mg of 3-methylcholanthrene were administered intratracheally to F344 rats maintained on a vitamin A-free diet and receiving 31.4 nmoles of RA per week by intragastric intubation. At 3, 5, and 10 weeks after intratracheal instillation of 3-methylcholanthrene, one group of 24 rats each was started on a weekly dose of 31,400 nmoles of RA; a control group was continued on the low-RA dose. Fifty-two weeks after 3-methylcholanthrene injection, the incidence of metaplastic lung nodules was found to be 3% in the combined high-RA-dose groups as compared with 42% in the low-RA-dose group. It is therefore concluded that RA has a significant effect on the postinitiation phase of preneoplastic lung nodules in rats.

¹ Research supported jointly by the Carcinogenesis Program of the National Cancer Institute and the Energy Research and Development Administration under contract with Union Carbide Corporation.

² To whom requests for reprints should be addressed.

Received 8/ 1/75. Accepted 11/14/75.

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