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Accelerated Regeneration of Trypsin-treated Surface Antigens of Simian Virus 40-transformed BALB/3T3 Cells Induced by X-irradiation¹

Cell Biology Section, Viral Biology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20014

The antigens of SV40-transformed BALB/3T3 cells measured by a radioisotopic footpad assay after removal by trypsin treatment regenerated in vitro in 3 to 6 hr. After X-irradiation with 3000 R, however, the antigens were regenerated to normal levels within 1 h. X-ray doses of between 1000 and 5000 R accelerated the regeneration of cell surface antigens, while X-irradiation with the larger dose of 8000 R did not. X-irradiation of nontrypsinized tumor cells was without effect. Possible mechanisms of this phenomenon are discussed.

¹ Supported in part by USPHS NO1-CP-22020 from the National Cancer Institute to Meloy Laboratories, Springfield, Va.

² On leave from St. Savas Hospital of the Hellenic Anticancer Institute, Athens, Greece, and holder of a scholarship from The Bodossaki Foundation, Athens, Greece.

Received 8/ 7/75. Accepted 12/ 8/75.

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