This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Scott, M. T. Articles by Warner, S. L. Search for Related Content PubMed PubMed Citation Articles by Scott, M. T. Articles by Warner, S. L.

The Accumulated Effects of Repeated Systemic or Local Injections of Low Doses of Corynebacterium parvum in Mice

Department of Experimental Immunobiology, Wellcome Research Laboratories, Beckenham, Kent BR3 3BS, England [M. T. S.], and Trudeau Institute, Inc., Saranac Lake, New York 12983 [S. L. W.]

The effects of 14 weekly injections, s.c. or i.v., of "human equivalent" doses (5.25 mg/sq m) of Corynebacterium parvum (CP) in mice have been compared. Both s.c. and i.v. CP caused significant splenomegaly and antibody to CP, but stimulation was considerably greater after i.v. CP. Delayed hypersensitivity levels to CP were similar after s.c. and i.v. injection. T-cell competence, as judged by phytohemagglutinin reactivity and delayed hypersensitivity to sheep cells, was unimpaired after s.c. CP and augmented by i.v. CP. Activated peritoneal macrophages capable of nonspecifically inhibiting tumor growth in vitro were detected only after i.v. CP, and in vivo resistance to tumor cell challenge was greater after CP administered i.v. than s.c.

¹ To whom requests for reprints should be addressed.

Received 10/28/75. Accepted 12/30/75.