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Growth Control of Heterologous Tissue Culture Cells in the Congenitally Athymic Nude Mouse¹

Department of Biology, John Muir College, The University of California, San Diego, La Jolla, California 92093

A variety of heterologous mammalian cells were inoculated into nude mice and scored for tumorigenicity. The cells tested were from primary cell cultures, established cell lines of neoplastic origin, established cell lines of nontumor origin, and primary cell cultures transformed by oncogenic viruses. Regardless of the animal species of origin, every cell line that was tumorigenic in some other animal host and every cell line of neoplastic origin was tumorigenic in nude mice. Several tissue culture cells lines capable of indefinite growth in vitro failed to form tumors in nude mice, and the basis of this growth suppression was investigated. The findings suggest that the failure of an established cell line to form tumors in nude mice is an authentic response to host-mediated growth-regulatory signals.

¹ This research was supported by Special Grant 741 from the California Division of the American Cancer Society, a grant from the University of California Cancer Research Coordinating Committee, NIH Grant 15503-02, and USPHS Grant 1 R01 CA16521-01A1 MBY.

² Supported by Postdoctoral Fellowship Award DE03366 from the USPHS.

³ Supported by NIH Career Development Award 1 K04 CA 00138-02.

Received 9/23/75. Accepted 12/22/75.

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