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Effect of Vitamin A Deficiency on Rat Colon Carcinogenesis by N-Methyl-N'-nitro-N-nitrosoguanidine¹

Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, New York 10595

The effect of vitamin A deficiency on the sensitivity of the colon to the carcinogenic effect of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), a direct-acting carcinogen, given intrarectally was studied in female Fischer rats. Animals maintained on Purina laboratory chow, semipurified vitamin A-free diet, or semipurified vitamine A-supplemented diet were given intrarectally 1.25, 0.63, or 0.31 mg MNNG 3 times weekly for 30 weeks and autopsied at the 45th week. The number of large bowel tumors per tumor-bearing rat was higher in animals receiving 1.25 mg MNNG compared to those given 0.63 or 0.31 mg. Vitamin A deficiency in rats given 1.25 mg MNNG significantly suppressed the large bowel tumor induction compared to rats fed adequate vitamin A. A high incidence of squamous cell papillomatosis of the urinary bladder was observed in rats fed vitamin A-free diet and given 1.25 mg MNNG. The present experiment suggests that the large intestine has a susceptibility that is different from that of the respiratory and urinary tracts to tumorigenic stimulation in vitamin A-deficient status.

¹ Supported in part by USPHS Contract NOI-CP-33208 and Grant CA-15400 from the National Cancer Institute.

² Visiting Investigator, Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, N. Y. 10595, on leave of absence from Akita University School of Medicine, Akita, Japan.

³ To whom requests for reprints should be addressed.

Received 8/ 8/75. Accepted 12/19/75.

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