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Effects of Adriamycin on Ultrastructure of Nucleoli in the Heart and Liver Cells of the Rat¹

Electron Microscopy Laboratory, Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77025

Ultrastructural studies of the effects of adriamycin on liver and cardiac cell nucleoli of the rat showed that nucleolar segregation occurred within 1 hr after an i.v. injection of a 40-mg/kg dose.

Between 3 and 27 hr after this single dose, liver cell nucleoli progressively reverted to a normal ultrastructure. Nucleoli of rat myocardial cells did not recover but underwent further fragmentation, segregation, and conversion to ring-shaped structures. The ultrastructural alterations of myocardial cell nucleoli may represent an important aspect of adriamycin toxicity.

¹ These studies were supported by the Cancer Research Center Grant CA-10893, P.5, awarded by the National Cancer Institute, Department of Health, Education and Welfare; the Davidson Fund; and a generous gift from Mrs. Jack Hutchins.

² Predoctoral Fellow supported by the USPHS Grant CA-05154.

Received 11/10/75. Accepted 1/16/76.

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