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Impaired Host Defense against XC Cell-induced Tumors in Thymectomized and in Bursectomized Chickens¹

Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140

XC cells originally derived from the tumor of a rat previously inoculated with the Prague strain of Rous sarcoma virus were used to induce tumors in chickens surgically thymectomized or bursectomized in the newly hatched period. Thymectomized chickens had a significantly higher incidence of tumors, larger tumors, and a higher tumor mortality, compared with control chickens, when both groups were given 5 x 10⁶ XC cells into the wing webs. Bursectomy could significantly influence the tumor size only. It appeared that the capacity of XC cells to induce tumors and the growth of such tumors were subject to immunological influence, with the thymus playing a major and the bursa of Fabricius a minor role under the conditions used.

¹ This work was supported by USPHS Grant CA 13347 from the National Cancer Institute, an NIH General Research Support Grant to Temple University, and by Grant IN-88F from the American Cancer Society.

Received 9/12/75. Accepted 2/ 3/76.

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